Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Thiamin (Vitamin B1)
250 mg
20,833%
Top Medical Research Studies
9
We explored the fascinating world of cyclotides, which are plant-derived peptides that can either support or suppress immune responses. Our focus was on a modified version of kalata B1, known as [T20K], which showed encouraging results in treating multiple sclerosis in preclinical studies.
Administering [T20K] led to significantly lower cytokine levels, minimal demyelination, and reduced inflammation in mice. In comparison to standard immunosuppressive drugs, [T20K] also showed lower mortality and morbidity rates. While the research is promising, more studies are needed to confirm these findings in humans.
Administering [T20K] led to significantly lower cytokine levels, minimal demyelination, and reduced inflammation in mice. In comparison to standard immunosuppressive drugs, [T20K] also showed lower mortality and morbidity rates. While the research is promising, more studies are needed to confirm these findings in humans.
Read More
9
We examined how ascorbic acid influences autoimmune disorders, particularly rheumatoid arthritis (RA). By injecting mice with ascorbic acid, we observed reduced disease severity and delayed onset compared to those receiving a similar saline solution.
Our research showed that ascorbic acid significantly lowered the levels of harmful autoantibodies and limited the development of autoreactive plasma cells. Additionally, it affected B cell differentiation and even promoted cell death within B cells, specifically by inhibiting certain signaling pathways.
In summary, ascorbic acid demonstrates promise as a potential treatment for managing RA symptoms and autoantibody production.
Our research showed that ascorbic acid significantly lowered the levels of harmful autoantibodies and limited the development of autoreactive plasma cells. Additionally, it affected B cell differentiation and even promoted cell death within B cells, specifically by inhibiting certain signaling pathways.
In summary, ascorbic acid demonstrates promise as a potential treatment for managing RA symptoms and autoantibody production.
Read More
8
We examined the role of the kinin B1 receptor in managing brain barrier issues linked to autoimmune disorders. Using a rat model of multiple sclerosis, we blocked this receptor and saw notable improvements.
The treatment reduced symptoms, recovered key proteins that strengthen the blood-brain barrier, and lessened inflammation in the brain. These findings highlight how targeting the B1 receptor could play a crucial role in protecting against the inflammation seen in autoimmune conditions.
The treatment reduced symptoms, recovered key proteins that strengthen the blood-brain barrier, and lessened inflammation in the brain. These findings highlight how targeting the B1 receptor could play a crucial role in protecting against the inflammation seen in autoimmune conditions.
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Most Useful Reviews
0
Worsened condition
6 people found this helpful
Dangerous excipient croscarmellose sodium! I began taking vitamin B1 for digestive and neuro-vegetative problems, but I developed colitis and intestinal spasms within a week. It worsened my condition. I ordered 10 jars, expecting relief, but "croscarmellose sodium" has made my intestines inflamed and permeable. It is ridiculous that the label claims it is guaranteed without colour, odour, or perfume.
Read More
7.5
Supports diabetic mother
2 people found this helpful
B-1, 250 mg, 100 tabs, excellent! I periodically order B group vitamins for my 65-year-old mother, who has type 2 diabetes and polyneuropathy, as an alternative to intramuscular injections. After five years of injections, she felt worn out both mentally and physically. We switched to drinking B group capsules, and she has shown noticeable improvement, thankfully maintaining her condition without worsening.
Read More
7.5
Quality supplement
Good supplement. I am satisfied with the quality and take it every day. I will order more as I feel an improvement!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8
- All Researches
9
We explored the fascinating world of cyclotides, which are plant-derived peptides that can either support or suppress immune responses. Our focus was on a modified version of kalata B1, known as [T20K], which showed encouraging results in treating multiple sclerosis in preclinical studies.
Administering [T20K] led to significantly lower cytokine levels, minimal demyelination, and reduced inflammation in mice. In comparison to standard immunosuppressive drugs, [T20K] also showed lower mortality and morbidity rates. While the research is promising, more studies are needed to confirm these findings in humans.
Administering [T20K] led to significantly lower cytokine levels, minimal demyelination, and reduced inflammation in mice. In comparison to standard immunosuppressive drugs, [T20K] also showed lower mortality and morbidity rates. While the research is promising, more studies are needed to confirm these findings in humans.
Read More
9
We examined how ascorbic acid influences autoimmune disorders, particularly rheumatoid arthritis (RA). By injecting mice with ascorbic acid, we observed reduced disease severity and delayed onset compared to those receiving a similar saline solution.
Our research showed that ascorbic acid significantly lowered the levels of harmful autoantibodies and limited the development of autoreactive plasma cells. Additionally, it affected B cell differentiation and even promoted cell death within B cells, specifically by inhibiting certain signaling pathways.
In summary, ascorbic acid demonstrates promise as a potential treatment for managing RA symptoms and autoantibody production.
Our research showed that ascorbic acid significantly lowered the levels of harmful autoantibodies and limited the development of autoreactive plasma cells. Additionally, it affected B cell differentiation and even promoted cell death within B cells, specifically by inhibiting certain signaling pathways.
In summary, ascorbic acid demonstrates promise as a potential treatment for managing RA symptoms and autoantibody production.
Read More
8
We assessed how a two-week reactive balance training program could help individuals with multiple sclerosis (PwMS) avoid falls. This study involved six training sessions where participants faced various balance challenges.
Results showed promising outcomes: PwMS experienced immediate and lasting improvements in their reactive stepping abilities, especially with quicker response times. Although this was a small, non-randomized trial, it suggests that this training approach is feasible and may effectively enhance balance in PwMS.
However, further research is needed to confirm these findings and understand its long-term benefits.
Results showed promising outcomes: PwMS experienced immediate and lasting improvements in their reactive stepping abilities, especially with quicker response times. Although this was a small, non-randomized trial, it suggests that this training approach is feasible and may effectively enhance balance in PwMS.
However, further research is needed to confirm these findings and understand its long-term benefits.
Read More
8
Podocyte exosomes affect endothelial injury
We investigated how exosomes from renal podocytes affect glomerular endothelial cell injury in lupus nephritis (LN). Our results showed that these exosomes, loaded with high mobility group protein B1 (HMGB1), were released in patients and animal models of LN. By using specific inhibitors, we found that blocking exosome release improved endothelial cell function. We also discovered that manipulating the levels of TRIM27—affected by HMGB1—significantly changed the damage to these cells. Overall, our findings suggest that targeting podocyte-derived exosomes could be a potential strategy to mitigate endothelial injury related to LN.
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8
We explored a unique case of a 65-year-old man with a history of idiopathic thrombocytopenic purpura (ITP) who developed Guillain-Barre and acute transverse myelitis overlap syndrome after contracting COVID-19.
Upon noticing symptoms like limb weakness and facial paralysis, he received immediate treatment including intravenous immune globulin and steroids. Remarkably, he made a significant recovery within eight weeks and was able to resume normal activities.
This case highlights the potential complications of COVID-19 and the importance of prompt intervention for patients with underlying immune conditions.
Upon noticing symptoms like limb weakness and facial paralysis, he received immediate treatment including intravenous immune globulin and steroids. Remarkably, he made a significant recovery within eight weeks and was able to resume normal activities.
This case highlights the potential complications of COVID-19 and the importance of prompt intervention for patients with underlying immune conditions.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
0
Worsened condition
6 people found this helpful
Dangerous excipient croscarmellose sodium! I began taking vitamin B1 for digestive and neuro-vegetative problems, but I developed colitis and intestinal spasms within a week. It worsened my condition. I ordered 10 jars, expecting relief, but "croscarmellose sodium" has made my intestines inflamed and permeable. It is ridiculous that the label claims it is guaranteed without colour, odour, or perfume.
Read More
7.5
Supports diabetic mother
2 people found this helpful
B-1, 250 mg, 100 tabs, excellent! I periodically order B group vitamins for my 65-year-old mother, who has type 2 diabetes and polyneuropathy, as an alternative to intramuscular injections. After five years of injections, she felt worn out both mentally and physically. We switched to drinking B group capsules, and she has shown noticeable improvement, thankfully maintaining her condition without worsening.
Read More
7.5
Quality supplement
Good supplement. I am satisfied with the quality and take it every day. I will order more as I feel an improvement!
Read More
Frequently Asked Questions
7.5
Supports diabetic mother
2 people found this helpful
B-1, 250 mg, 100 tabs, excellent! I periodically order B group vitamins for my 65-year-old mother, who has type 2 diabetes and polyneuropathy, as an alternative to intramuscular injections. After five years of injections, she felt worn out both mentally and physically. We switched to drinking B group capsules, and she has shown noticeable improvement, thankfully maintaining her condition without worsening.
7.5
Quality supplement
Good supplement. I am satisfied with the quality and take it every day. I will order more as I feel an improvement!
0
Worsened condition
6 people found this helpful
Dangerous excipient croscarmellose sodium! I began taking vitamin B1 for digestive and neuro-vegetative problems, but I developed colitis and intestinal spasms within a week. It worsened my condition. I ordered 10 jars, expecting relief, but "croscarmellose sodium" has made my intestines inflamed and permeable. It is ridiculous that the label claims it is guaranteed without colour, odour, or perfume.
9
We explored the fascinating world of cyclotides, which are plant-derived peptides that can either support or suppress immune responses. Our focus was on a modified version of kalata B1, known as [T20K], which showed encouraging results in treating multiple sclerosis in preclinical studies.
Administering [T20K] led to significantly lower cytokine levels, minimal demyelination, and reduced inflammation in mice. In comparison to standard immunosuppressive drugs, [T20K] also showed lower mortality and morbidity rates. While the research is promising, more studies are needed to confirm these findings in humans.
Administering [T20K] led to significantly lower cytokine levels, minimal demyelination, and reduced inflammation in mice. In comparison to standard immunosuppressive drugs, [T20K] also showed lower mortality and morbidity rates. While the research is promising, more studies are needed to confirm these findings in humans.
9
We examined how ascorbic acid influences autoimmune disorders, particularly rheumatoid arthritis (RA). By injecting mice with ascorbic acid, we observed reduced disease severity and delayed onset compared to those receiving a similar saline solution.
Our research showed that ascorbic acid significantly lowered the levels of harmful autoantibodies and limited the development of autoreactive plasma cells. Additionally, it affected B cell differentiation and even promoted cell death within B cells, specifically by inhibiting certain signaling pathways.
In summary, ascorbic acid demonstrates promise as a potential treatment for managing RA symptoms and autoantibody production.
Our research showed that ascorbic acid significantly lowered the levels of harmful autoantibodies and limited the development of autoreactive plasma cells. Additionally, it affected B cell differentiation and even promoted cell death within B cells, specifically by inhibiting certain signaling pathways.
In summary, ascorbic acid demonstrates promise as a potential treatment for managing RA symptoms and autoantibody production.
References
- Mishra R, Agarwal P, Sharma A, Mittal M, Gulati P, et al. Plant-derived Cyclotides in Immunomodulation and their Therapeutic Potential. Protein Pept Lett. 2025. 10.2174/0109298665364479250214101422
- Peterson DS, Monaghan AS, Hooyman A, Trevino JL, Kratz K. Feasibility and preliminary effectiveness of a 2-week in-place reactive balance training program in people with multiple sclerosis. Mult Scler Relat Disord. 2025;95:106346. 10.1016/j.msard.2025.106346
- Liu J, Zhao T, Cui H, Tian Y, Miao X, et al. HMGB1 Encapsulated in Podocyte-Derived Exosomes Plays a Central Role in Glomerular Endothelial Cell Injury in Lupus Nephritis by Regulating TRIM27 Expression. Lab Invest. 2025;105:104096. 10.1016/j.labinv.2025.104096
- Li Q, Duan D, Wang X, Sun M, Liu Y, et al. [High mobility group protein B1(HMGB1) promotes myeloid dendritic cell maturation and increases Th17 cell/Treg cell ratio in patients with immune primary thrombocytopenia]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2025;41:45.
- Chen R, Wang L, Wang B, Song X, Liu X. Concurrent Guillain-Barre/acute transverse myelitis overlap syndrome after COVID-19 infection in a patient with ITP: A case report. Medicine (Baltimore). 2024;103:e40346. 10.1097/MD.0000000000040346
- Sulkowski G, Dąbrowska-Bouta B, Frontczak-Baniewicz M, Strużyńska L. Involvement of the Kinin B1 Receptor in Increased Permeability of Cerebral Microvessels in Rats Subjected to Autoimmune Encephalomyelitis. Cells. 2024;13. 10.3390/cells13191641
- Bhoj PS, Nocito C, Togre NS, Winfield M, Lubinsky C, et al. Tissue Kallikrein-1 Suppresses Type I Interferon Responses and Reduces Depressive-Like Behavior in the MRL/lpr Lupus-Prone Mouse Model. Int J Mol Sci. 2024;25. 10.3390/ijms251810080
- Muraoka S, Brodie WD, Mattichak MN, Gurrea-Rubio M, Ikari Y, et al. Targeting CD13/Aminopeptidase N as a Novel Therapeutic Approach for Scleroderma Fibrosis. Arthritis Rheumatol. 2025;77:80. 10.1002/art.42973
- Zoshima T, Baba T, Nakatani K, Nagata M, Mukaida N, et al. The CCL2-CCR2 axis determines whether glomerular endocapillary hypercellularity or wire-loop lesions develop through glomerular macrophage and neutrophil infiltration in lupus nephritis. J Pathol. 2024;264:174. 10.1002/path.6331
- Yin Y, Wu S. Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies. Cell Commun Signal. 2024;22:373. 10.1186/s12964-024-01756-x
- Wang T, Rathee A, Pemberton PA, Lood C. Exogenous serpin B1 restricts immune complex-mediated NET formation via inhibition of a chymotrypsin-like protease and enhances microbial phagocytosis. J Biol Chem. 2024;300:107533. 10.1016/j.jbc.2024.107533
